Subacute Necrotizing Encephalomyelopathy and MT-CO1
Ontology
The Gene Ontology is a an initiative to compile and represent the gene and it's products across all organisms with symbolic terms. There are many databases available, and each have their own advantages. The three below have been chosen due to their ease of use and free availability to all researchers. MT-CO1 has been searched through the databases to determine the biological processes it is involved in, cellular component, and molecular function.
The Gene Ontology Project
Despite the gene specific emphasis in the name of the resource the Gene Ontology Project was useful in finding ontologies associated with Cytochrome c Oxidase subunit 1. The project uses AmiGO to retrieve the relevant information [1].
There were 15 ontologies found with the Gene Ontology project, and they were divided into 3 groups (Biological Process, Cellular Component, Molecular Function). These 15 ontologies are listed below along with their accession numbers.
There were 15 ontologies found with the Gene Ontology project, and they were divided into 3 groups (Biological Process, Cellular Component, Molecular Function). These 15 ontologies are listed below along with their accession numbers.
Biological Process:
Aerobic Respiration (GO:0009060)
Electron Transport Chain (GO:0022900)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Transport (GO:0006810)
Aerobic Respiration (GO:0009060)
Electron Transport Chain (GO:0022900)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Transport (GO:0006810)
Cellular Component:
Integral to Membrane (GO:0016021)
Membrane (GO:0016020)
Mitochondrial inner Membrane (GO:005743)
Mitochondrion (GO:0005739)
Respiratory Chain (GO:0070469)
Integral to Membrane (GO:0016021)
Membrane (GO:0016020)
Mitochondrial inner Membrane (GO:005743)
Mitochondrion (GO:0005739)
Respiratory Chain (GO:0070469)
Molecular Function:
Cytochrome-c Oxidase Activity (GO:0004129)
Electron Carrier Activity (GO:0009055)
Heme Binding (GO:0020037)
Metal Ion Binding (GO:0046872)
Oxidoreductase Activity (GO:0016491)
Protein Binding (GO:0005515)
Cytochrome-c Oxidase Activity (GO:0004129)
Electron Carrier Activity (GO:0009055)
Heme Binding (GO:0020037)
Metal Ion Binding (GO:0046872)
Oxidoreductase Activity (GO:0016491)
Protein Binding (GO:0005515)
Go All Viewer Analysis
Go All Viewer is able to retrieve information relevant to a protein's ontology and compile it visually. Go All was able to obtain 16 ontologies for Cytochrome c Oxidase Subunit 1 in humans (Listed below).
QuickGO
QuickGO is an online database designed by the European Bioinformatics Institute. The QuickGO was able to obtain 17 ontologies for Cytochrome c Oxidase subunit 1 in humans (listed below).
Biological Process:
Oxidation Reduction (GO:0055114)
Aerobic Repiration (GO: 0009060)
Transport (GO:0006810)
Electron Transport Chain (GO:0022900)
Mitochondrial Electron transport,
Cytochrome c to oxygen (GO:0006123)
Oxidation Reduction (GO:0055114)
Aerobic Repiration (GO: 0009060)
Transport (GO:0006810)
Electron Transport Chain (GO:0022900)
Mitochondrial Electron transport,
Cytochrome c to oxygen (GO:0006123)
Cellular Component:
Mitochondrion (GO:0005739)
Integral to membrane (GO:0016021)
Membrane (GO:0016020)
Respiratory Chain (GO:0070469)
Mitochondrial Inner Membrane (GO:0005743)
Mitochondrion (GO:0005739)
Integral to membrane (GO:0016021)
Membrane (GO:0016020)
Respiratory Chain (GO:0070469)
Mitochondrial Inner Membrane (GO:0005743)
Molecular function:
Electron Carrier Activity (GO:0009055)
Protein Binding (GO:0005515)
Metal Ion Binding (GO:0046872)
Iron Ion Binding (GO:0005506)
Cytochrome c Oxidase Activity (GO:0004129)
Heme Binding (GO:0020037)
Oxidoreducatse Activity (GO:0016491)
Electron Carrier Activity (GO:0009055)
Protein Binding (GO:0005515)
Metal Ion Binding (GO:0046872)
Iron Ion Binding (GO:0005506)
Cytochrome c Oxidase Activity (GO:0004129)
Heme Binding (GO:0020037)
Oxidoreducatse Activity (GO:0016491)
